Assay Detail
Binding
CHEMBL829020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.75 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316983 | — | — | 1 | 8.96 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.82 |
| CHEMBL372020 | — | — | 1 | 8.62 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316983 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL372020 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 2.6 | nM | 8.59 |