Assay Detail
Binding
CHEMBL829029
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Inhibition of [3H]prazosin bindign to Adrenergic alpha 1 receptor from rat brain cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.69 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189384 | — | — | 1 | 7.12 |
| CHEMBL193182 | — | — | 1 | 6.89 |
| CHEMBL189890 | — | — | 1 | 6.85 |
| CHEMBL191226 | — | — | 1 | 6.45 |
| CHEMBL426813 | — | — | 1 | 6.13 |
| CHEMBL364530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189384 | — | Ki | = | 75.3 | nM | 7.12 |
| CHEMBL193182 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL189890 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL191226 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL426813 | — | Ki | = | 747.0 | nM | 6.13 |
| CHEMBL364530 | — | Ki | > | 100000.0 | nM | - |