Assay Detail
Binding
CHEMBL829030
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Inhibition of [3H]8-OH-DPAT binding to Serotonin 5-HT1A receptor from rat brain cortex
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.94 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189384 | — | — | 1 | 10.68 |
| CHEMBL364530 | — | — | 1 | 8.67 |
| CHEMBL189890 | — | — | 1 | 8.47 |
| CHEMBL193182 | — | — | 1 | 8.38 |
| CHEMBL191226 | — | — | 1 | 8.29 |
| CHEMBL426813 | — | — | 1 | 8.15 |
| CHEMBL362999 | — | — | 1 | 7.57 |
| CHEMBL191574 | — | — | 1 | 7.52 |
| CHEMBL192348 | — | — | 1 | 7.35 |
| CHEMBL192828 | — | — | 1 | 7.30 |
| CHEMBL191221 | — | — | 1 | 6.42 |
| CHEMBL365309 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189384 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL364530 | — | Ki | = | 2.14 | nM | 8.67 |
| CHEMBL189890 | — | Ki | = | 3.36 | nM | 8.47 |
| CHEMBL193182 | — | Ki | = | 4.13 | nM | 8.38 |
| CHEMBL191226 | — | Ki | = | 5.13 | nM | 8.29 |
| CHEMBL426813 | — | Ki | = | 7.12 | nM | 8.15 |
| CHEMBL362999 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL191574 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL192348 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL192828 | — | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL191221 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL365309 | — | Ki | = | 382.0 | nM | 6.42 |