Assay Detail
Binding
CHEMBL829043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1A receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.59 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606547 | — | — | 1 | 6.77 |
| CHEMBL606556 | — | — | 1 | 6.70 |
| CHEMBL2113386 | — | — | 1 | 6.63 |
| CHEMBL609742 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606547 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL606556 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2113386 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL609742 | — | Ki | = | 552.0 | nM | 6.26 |