Assay Detail
Binding
CHEMBL829074
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Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.74 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216992 | — | — | 1 | 9.22 |
| CHEMBL386784 | — | — | 1 | 9.00 |
| CHEMBL263587 | — | — | 1 | 8.92 |
| CHEMBL410047 | — | — | 1 | 8.85 |
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 8.80 |
| CHEMBL452157 | — | — | 1 | 8.74 |
| CHEMBL436962 | — | — | 1 | 8.48 |
| CHEMBL413924 | — | — | 1 | 7.00 |
| CHEMBL411600 | — | — | 1 | 6.67 |
| CHEMBL367125 | — | — | 1 | 6.64 |
| CHEMBL262258 | — | — | 1 | 6.21 |
| CHEMBL438285 | — | — | 1 | 6.11 |
| CHEMBL265836 | — | — | 1 | 6.03 |
| CHEMBL4649897 | — | — | 1 | - |
| CHEMBL413413 | — | — | 1 | - |
| CHEMBL409747 | — | — | 1 | - |
| CHEMBL413888 | — | — | 1 | - |
| CHEMBL441202 | — | — | 1 | - |
| CHEMBL407027 | — | — | 1 | - |
| CHEMBL438987 | — | — | 1 | - |
| CHEMBL266346 | — | — | 1 | - |
| CHEMBL387198 | — | — | 1 | - |
| CHEMBL265839 | — | — | 1 | - |
| CHEMBL2373274 | — | — | 1 | - |
| CHEMBL406095 | — | — | 1 | - |
| CHEMBL2374243 | — | — | 1 | - |
| CHEMBL2374244 | — | — | 1 | - |
| CHEMBL439135 | — | — | 1 | - |
| CHEMBL216676 | — | — | 1 | - |
| CHEMBL439111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216992 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL386784 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL263587 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL410047 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1823872 | SOMATOSTATIN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL452157 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL436962 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL413924 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL411600 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL367125 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL262258 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL438285 | — | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL265836 | — | IC50 | = | 932.0 | nM | 6.03 |
| CHEMBL387005 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL411411 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4649895 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL269023 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL429164 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL384072 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL440074 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2373256 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL409952 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL414100 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL437827 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL437348 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL411001 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL425973 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL438630 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL368304 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL412509 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL411002 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL387198 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL439111 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL216676 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL439135 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2374244 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2374243 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL406095 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2373274 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL265839 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL411109 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL266346 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL438987 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL407027 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL441202 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL413888 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL409747 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL413413 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4649897 | — | IC50 | > | 1000.0 | nM | - |