Assay Detail
Binding
CHEMBL829083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human VEGFR 2 in DELFIA assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190161 | — | — | 1 | 8.52 |
| CHEMBL192856 | — | — | 1 | 8.40 |
| CHEMBL278472 | — | — | 1 | 8.30 |
| CHEMBL189995 | — | — | 1 | 8.30 |
| CHEMBL365727 | — | — | 1 | 8.22 |
| CHEMBL191023 | — | — | 1 | 8.22 |
| CHEMBL187396 | — | — | 1 | 8.22 |
| CHEMBL191070 | — | — | 1 | 8.15 |
| CHEMBL189691 | — | — | 1 | 8.10 |
| CHEMBL425363 | — | — | 1 | 8.10 |
| CHEMBL339856 | — | — | 1 | 8.05 |
| CHEMBL191389 | — | — | 1 | 7.85 |
| CHEMBL363551 | — | — | 1 | 7.82 |
| CHEMBL189059 | — | — | 1 | 7.68 |
| CHEMBL365377 | — | — | 1 | 7.60 |
| CHEMBL190389 | — | — | 1 | 7.34 |
| CHEMBL188087 | — | — | 1 | 7.29 |
| CHEMBL425552 | — | — | 1 | 7.27 |
| CHEMBL189851 | — | — | 1 | 7.21 |
| CHEMBL365140 | — | — | 1 | 7.15 |
| CHEMBL190866 | — | — | 1 | 7.08 |
| CHEMBL190405 | — | — | 1 | 7.02 |
| CHEMBL190188 | — | — | 1 | 6.96 |
| CHEMBL189584 | PD-173074 | — | 1 | 6.92 |
| CHEMBL190162 | — | — | 1 | 6.89 |
| CHEMBL189322 | — | — | 1 | 6.75 |
| CHEMBL190991 | — | — | 1 | 6.75 |
| CHEMBL191265 | — | — | 1 | 6.75 |
| CHEMBL189542 | — | — | 1 | 6.75 |
| CHEMBL190783 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190161 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL192856 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL189995 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL278472 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL365727 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191023 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL187396 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191070 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL189691 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL425363 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL339856 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL191389 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL363551 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL189059 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL365377 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL190389 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL188087 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL425552 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL189851 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL365140 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL190866 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL190405 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL190188 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL189584 | PD-173074 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL190162 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL189322 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL190991 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL191265 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL189542 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL190783 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL188978 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL370328 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL189325 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL188648 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL190210 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL191189 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL362502 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL190132 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL190351 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL363304 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL365133 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL361886 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL191372 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL189628 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL188431 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL192668 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL190443 | — | IC50 | = | 55000.0 | nM | 4.26 |