Compound Detail
CHEMBL189542
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Basic Information
| ChEMBL ID | CHEMBL189542 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMRQZYNUHURXII-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
462.6
MW (Da)
5.75
ALogP
5
HBA
3
HBD
82.2
PSA (Ų)
0.33
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL3655 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.7 | 6.61 | 200.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 6.35 | 6.35 | 450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 110.0 | nM | 6.96 | Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by avian c-Src ... | 16000000 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 180.0 | nM | 6.75 | Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human VEGFR ... | 16000000 |
| Fibroblast growth factor receptor 1 | IC50 | = | 200.0 | nM | 6.7 | Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human FGFR1 ... | 16000000 |
| Fibroblast growth factor receptor 1 | IC50 | = | 300.0 | nM | 6.52 | Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human fibrob... | 16000000 |
| Platelet-derived growth factor receptor beta | IC50 | = | 450.0 | nM | 6.35 | Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by mouse platel... | 16000000 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16000000 | 10.1021/jm0500931 | Fibroblast growth factor receptor 1 | 2 |
| 16000000 | 10.1021/jm0500931 | Vascular endothelial growth factor receptor 2 | 1 |
| 16000000 | 10.1021/jm0500931 | Platelet-derived growth factor receptor beta | 1 |
| 16000000 | 10.1021/jm0500931 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine