Assay Detail
Binding
CHEMBL829923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human fibroblast growth factor receptor 1
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.79 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189059 | — | — | 1 | 7.72 |
| CHEMBL188087 | — | — | 1 | 7.68 |
| CHEMBL190389 | — | — | 1 | 7.62 |
| CHEMBL190161 | — | — | 1 | 7.62 |
| CHEMBL189995 | — | — | 1 | 7.62 |
| CHEMBL365377 | — | — | 1 | 7.60 |
| CHEMBL191023 | — | — | 1 | 7.60 |
| CHEMBL191389 | — | — | 1 | 7.58 |
| CHEMBL192856 | — | — | 1 | 7.55 |
| CHEMBL189584 | PD-173074 | — | 1 | 7.55 |
| CHEMBL190162 | — | — | 1 | 7.54 |
| CHEMBL187396 | — | — | 1 | 7.52 |
| CHEMBL339856 | — | — | 1 | 7.51 |
| CHEMBL190188 | — | — | 1 | 7.50 |
| CHEMBL189851 | — | — | 1 | 7.48 |
| CHEMBL191070 | — | — | 1 | 7.48 |
| CHEMBL190783 | — | — | 1 | 7.46 |
| CHEMBL365140 | — | — | 1 | 7.42 |
| CHEMBL191265 | — | — | 1 | 7.36 |
| CHEMBL278472 | — | — | 1 | 7.31 |
| CHEMBL425363 | — | — | 1 | 7.28 |
| CHEMBL363551 | — | — | 1 | 7.22 |
| CHEMBL189691 | — | — | 1 | 7.16 |
| CHEMBL188978 | — | — | 1 | 7.06 |
| CHEMBL365727 | — | — | 1 | 7.03 |
| CHEMBL191189 | — | — | 1 | 6.92 |
| CHEMBL425552 | — | — | 1 | 6.72 |
| CHEMBL189542 | — | — | 1 | 6.52 |
| CHEMBL188648 | — | — | 1 | 6.46 |
| CHEMBL190991 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189059 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL188087 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL190161 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL189995 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL190389 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL365377 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL191023 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL191389 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL192856 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL189584 | PD-173074 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL190162 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL187396 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL339856 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL190188 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL191070 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL189851 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL190783 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL365140 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL191265 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL278472 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL425363 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL363551 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL189691 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL188978 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL365727 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL191189 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL425552 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL189542 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL188648 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL190991 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL189322 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL190866 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL190132 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL190405 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL189325 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL190351 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL370328 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL361886 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL190210 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL362502 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL190443 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL189628 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL365133 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL363304 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL191372 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL188431 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL192668 | — | IC50 | > | 50000.0 | nM | - |