Assay Detail
Binding
CHEMBL832302
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Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by mouse platelet-derived growth factor receptor-beta
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.16 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190162 | — | — | 1 | 6.80 |
| CHEMBL189542 | — | — | 1 | 6.35 |
| CHEMBL365377 | — | — | 1 | 6.32 |
| CHEMBL190188 | — | — | 1 | 6.27 |
| CHEMBL191389 | — | — | 1 | 6.21 |
| CHEMBL425552 | — | — | 1 | 5.92 |
| CHEMBL191023 | — | — | 1 | 5.58 |
| CHEMBL190161 | — | — | 1 | 5.44 |
| CHEMBL188648 | — | — | 1 | 5.40 |
| CHEMBL191189 | — | — | 1 | 5.33 |
| CHEMBL192856 | — | — | 1 | 5.30 |
| CHEMBL190389 | — | — | 1 | 5.19 |
| CHEMBL190132 | — | — | 1 | 5.06 |
| CHEMBL365727 | — | — | 1 | 4.96 |
| CHEMBL190351 | — | — | 1 | 4.92 |
| CHEMBL189584 | PD-173074 | — | 1 | 4.85 |
| CHEMBL187396 | — | — | 1 | 4.82 |
| CHEMBL189995 | — | — | 1 | 4.80 |
| CHEMBL363551 | — | — | 1 | 4.75 |
| CHEMBL425363 | — | — | 1 | 4.64 |
| CHEMBL190783 | — | — | 1 | 4.57 |
| CHEMBL189691 | — | — | 1 | 4.57 |
| CHEMBL188087 | — | — | 1 | 4.52 |
| CHEMBL189059 | — | — | 1 | 4.51 |
| CHEMBL278472 | — | — | 1 | 4.50 |
| CHEMBL189851 | — | — | 1 | 4.35 |
| CHEMBL339856 | — | — | 1 | 4.35 |
| CHEMBL191265 | — | — | 1 | 4.30 |
| CHEMBL189325 | — | — | 1 | - |
| CHEMBL189628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190162 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL189542 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL365377 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL190188 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL191389 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL425552 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL191023 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL190161 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL188648 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL191189 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL192856 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL190389 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL190132 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL365727 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL190351 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL189584 | PD-173074 | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL187396 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL189995 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL363551 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL425363 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL190783 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL189691 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL188087 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL189059 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL278472 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL189851 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL339856 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL191265 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL188431 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190210 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190443 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL363304 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL191372 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL192668 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL365140 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL188978 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL191070 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL361886 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL370328 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190405 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL189322 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190991 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL365133 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190866 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL362502 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL189628 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL189325 | — | IC50 | > | 50000.0 | nM | - |