Assay Detail
Binding
CHEMBL832920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glutamate/tyrosine (4:1) copolymer phosphorylation by human FGFR1 in DELFIA assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278472 | — | — | 1 | 8.40 |
| CHEMBL192856 | — | — | 1 | 8.22 |
| CHEMBL191023 | — | — | 1 | 8.22 |
| CHEMBL190161 | — | — | 1 | 8.22 |
| CHEMBL365377 | — | — | 1 | 8.15 |
| CHEMBL191389 | — | — | 1 | 8.15 |
| CHEMBL187396 | — | — | 1 | 8.15 |
| CHEMBL425363 | — | — | 1 | 8.10 |
| CHEMBL191070 | — | — | 1 | 8.05 |
| CHEMBL365727 | — | — | 1 | 8.00 |
| CHEMBL189691 | — | — | 1 | 8.00 |
| CHEMBL189059 | — | — | 1 | 7.96 |
| CHEMBL339856 | — | — | 1 | 7.92 |
| CHEMBL190389 | — | — | 1 | 7.89 |
| CHEMBL190188 | — | — | 1 | 7.80 |
| CHEMBL190162 | — | — | 1 | 7.80 |
| CHEMBL189851 | — | — | 1 | 7.75 |
| CHEMBL189584 | PD-173074 | — | 1 | 7.72 |
| CHEMBL188087 | — | — | 1 | 7.68 |
| CHEMBL188978 | — | — | 1 | 7.34 |
| CHEMBL365140 | — | — | 1 | 7.31 |
| CHEMBL191265 | — | — | 1 | 7.08 |
| CHEMBL190783 | — | — | 1 | 7.07 |
| CHEMBL425552 | — | — | 1 | 6.85 |
| CHEMBL190991 | — | — | 1 | 6.72 |
| CHEMBL189542 | — | — | 1 | 6.70 |
| CHEMBL191189 | — | — | 1 | 6.66 |
| CHEMBL189322 | — | — | 1 | 6.58 |
| CHEMBL190405 | — | — | 1 | 6.48 |
| CHEMBL190866 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278472 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL192856 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL190161 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191023 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL365377 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL191389 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL187396 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL425363 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL191070 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL365727 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL189691 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL189059 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL339856 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL190389 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL190162 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL190188 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL189851 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL189584 | PD-173074 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL188087 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL188978 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL365140 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL191265 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL190783 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL425552 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL190991 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL189542 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL191189 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL189322 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL190405 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL190866 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL188648 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL190210 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL362502 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL189325 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL190351 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL370328 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL190132 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL365133 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL192668 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL363304 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL189628 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL191372 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL188431 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL190443 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL361886 | — | IC50 | = | 23000.0 | nM | 4.64 |