Assay Detail
Binding
CHEMBL829118
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Percent inhibition of [3H]DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.38 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113045 | — | — | 1 | 5.83 |
| CHEMBL187458 | — | — | 1 | 5.76 |
| CHEMBL188967 | — | — | 1 | 5.73 |
| CHEMBL188958 | — | — | 1 | 5.71 |
| CHEMBL191270 | — | — | 1 | 5.52 |
| CHEMBL366216 | — | — | 1 | 5.41 |
| CHEMBL363419 | — | — | 1 | 4.58 |
| CHEMBL446698 | — | — | 1 | 4.47 |
| CHEMBL188343 | REVERSINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113045 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL187458 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL188967 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL188958 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL191270 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL366216 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL363419 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL446698 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL188343 | REVERSINE | Ki | > | 10000.0 | nM | - |