Assay Detail
Binding
CHEMBL829136
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Inhibitory concentration against human cathepsin L by fluorescence assay using 5 uM Cbz-Phe-Arg-AMC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A structural screening approach to ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.96 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194068 | — | — | 1 | 6.82 |
| CHEMBL196896 | — | — | 1 | 6.39 |
| CHEMBL196240 | — | — | 1 | 6.34 |
| CHEMBL195963 | — | — | 1 | 6.18 |
| CHEMBL196298 | — | — | 1 | 6.00 |
| CHEMBL193582 | — | — | 1 | 5.77 |
| CHEMBL197509 | — | — | 1 | 5.58 |
| CHEMBL371749 | — | — | 1 | 5.36 |
| CHEMBL195301 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194068 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL196896 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL196240 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL195963 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL196298 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL193582 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL197509 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL371749 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL195301 | — | IC50 | = | 6800.0 | nM | 5.17 |