Assay Detail
Binding
CHEMBL829137
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Inhibitory concentration against human cathepsin V by fluorescence assay using 2 uM Cbz-Phe-Arg-AMC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A structural screening approach to ketoamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.53 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194068 | — | — | 1 | 7.54 |
| CHEMBL196896 | — | — | 1 | 7.10 |
| CHEMBL193582 | — | — | 1 | 6.75 |
| CHEMBL196298 | — | — | 1 | 6.72 |
| CHEMBL196240 | — | — | 1 | 6.54 |
| CHEMBL195963 | — | — | 1 | 6.47 |
| CHEMBL197509 | — | — | 1 | 6.41 |
| CHEMBL195301 | — | — | 1 | 5.70 |
| CHEMBL371749 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194068 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL196896 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL193582 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL196298 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL196240 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL195963 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL197509 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL195301 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL371749 | — | IC50 | = | 2800.0 | nM | 5.55 |