Assay Detail
Binding
CHEMBL829151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required against human histamine H3 receptor was determined by the inhibition of the cAMP stimulated beta-galactosidase transcription in SK-N-MC cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.73 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | — | 1 | 6.00 |
| CHEMBL362163 | — | — | 1 | 6.00 |
| CHEMBL186456 | — | — | 1 | 6.00 |
| CHEMBL128613 | — | — | 1 | 5.80 |
| CHEMBL187210 | — | — | 1 | 5.50 |
| CHEMBL186108 | — | — | 1 | 5.50 |
| CHEMBL365257 | — | — | 1 | 5.50 |
| CHEMBL185951 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL362163 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL186456 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL128613 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL187210 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL186108 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL365257 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL185951 | — | EC50 | = | 3162.28 | nM | 5.50 |