Assay Detail
Binding
CHEMBL829154
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Inhibitory activity against human erythrocyte acetylcholinesterase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.49 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 1 | 9.49 |
| CHEMBL143812 | — | — | 1 | 9.49 |
| CHEMBL341658 | — | — | 1 | 8.68 |
| CHEMBL292314 | — | — | 1 | 8.00 |
| CHEMBL61715 | — | — | 1 | 7.55 |
| CHEMBL132030 | — | — | 1 | 7.10 |
| CHEMBL61533 | — | — | 1 | 7.06 |
| CHEMBL60119 | — | — | 1 | 7.00 |
| CHEMBL1161717 | — | — | 1 | 6.80 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.60 |
| CHEMBL132260 | — | — | 1 | 6.58 |
| CHEMBL302842 | — | — | 1 | 6.46 |
| CHEMBL61930 | — | — | 1 | 6.33 |
| CHEMBL1161718 | — | — | 1 | 6.30 |
| CHEMBL62084 | — | — | 1 | 6.26 |
| CHEMBL132365 | — | — | 1 | 6.21 |
| CHEMBL1161720 | — | — | 1 | 5.82 |
| CHEMBL1161716 | — | — | 1 | 5.77 |
| CHEMBL59977 | — | — | 1 | 5.52 |
| CHEMBL1161719 | — | — | 1 | 5.43 |
| CHEMBL61486 | — | — | 1 | 5.42 |
| CHEMBL61929 | — | — | 1 | 5.28 |
| CHEMBL133441 | — | — | 1 | 5.20 |
| CHEMBL62085 | — | — | 1 | 5.09 |
| CHEMBL134240 | — | — | 1 | 5.00 |
| CHEMBL130373 | — | — | 1 | 4.38 |
| CHEMBL165292 | — | — | 1 | - |
| CHEMBL350496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL143812 | — | IC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL341658 | — | IC50 | = | 2.089 | nM | 8.68 |
| CHEMBL292314 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL61715 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL132030 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL61533 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL60119 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1161717 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL95 | TACRINE | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL132260 | — | IC50 | = | 263.03 | nM | 6.58 |
| CHEMBL302842 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL61930 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL1161718 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL62084 | — | IC50 | = | 549.54 | nM | 6.26 |
| CHEMBL132365 | — | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL1161720 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL1161716 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL59977 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL1161719 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL61486 | — | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL61929 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL133441 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL62085 | — | IC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL134240 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL130373 | — | IC50 | = | 41686.94 | nM | 4.38 |
| CHEMBL165292 | — | IC50 | < | 100000.0 | nM | - |
| CHEMBL350496 | — | IC50 | < | 100000.0 | nM | - |