Assay Detail
Binding
CHEMBL829159
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In vitro inhibitory activity against human erythrocyte acetylcholinesterase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.34 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 8.74 |
| CHEMBL352500 | — | — | 1 | 8.35 |
| CHEMBL134057 | — | — | 1 | 8.03 |
| CHEMBL1161714 | — | — | 1 | 7.54 |
| CHEMBL431844 | — | — | 1 | 7.50 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.47 |
| CHEMBL368196 | — | — | 1 | 7.37 |
| CHEMBL369661 | — | — | 1 | 7.16 |
| CHEMBL355740 | — | — | 1 | 7.07 |
| CHEMBL1161715 | — | — | 1 | 6.79 |
| CHEMBL62084 | — | — | 1 | 6.13 |
| CHEMBL172118 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL352500 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL134057 | — | IC50 | = | 9.333 | nM | 8.03 |
| CHEMBL1161714 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL431844 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL95 | TACRINE | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL368196 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL369661 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL355740 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL1161715 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL62084 | — | IC50 | = | 741.31 | nM | 6.13 |
| CHEMBL172118 | — | IC50 | = | 1096.48 | nM | 5.96 |