Assay Detail
Binding
CHEMBL829239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cells
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.13 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175456 | — | — | 4 | 10.01 |
| CHEMBL424969 | — | — | 1 | 7.62 |
| CHEMBL175689 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175456 | — | Kd | = | 0.097 | nM | 10.01 |
| CHEMBL175456 | — | Kd | = | 2.28 | nM | 8.64 |
| CHEMBL175456 | — | Kd | = | 4.3 | nM | 8.37 |
| CHEMBL424969 | — | Kd | = | 23.8 | nM | 7.62 |
| CHEMBL175456 | — | Kd | = | 72.0 | nM | 7.14 |
| CHEMBL175689 | — | Kd | = | 97.8 | nM | 7.01 |