Assay Detail
Binding
CHEMBL829259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against rat cortex Acetylcholinesterase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.96 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185302 | — | — | 1 | 8.22 |
| CHEMBL184784 | — | — | 1 | 7.99 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.65 |
| CHEMBL185254 | — | — | 1 | 6.64 |
| CHEMBL181816 | — | — | 1 | 6.18 |
| CHEMBL185252 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185302 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL184784 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL95 | TACRINE | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL185254 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL181816 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL185252 | — | IC50 | = | 869.0 | nM | 6.06 |