Assay Detail
Binding
CHEMBL829289
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Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.62 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189938 | — | — | 1 | 7.30 |
| CHEMBL62136 | T091317 | — | 1 | 7.26 |
| CHEMBL59030 | — | — | 1 | 7.10 |
| CHEMBL364666 | — | — | 1 | 7.00 |
| CHEMBL190901 | — | — | 1 | 6.89 |
| CHEMBL189228 | — | — | 1 | 6.56 |
| CHEMBL191263 | — | — | 1 | 6.52 |
| CHEMBL191419 | — | — | 1 | 6.24 |
| CHEMBL189532 | — | — | 1 | 6.14 |
| CHEMBL370285 | — | — | 1 | 6.05 |
| CHEMBL158781 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189938 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL62136 | T091317 | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL59030 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL364666 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL190901 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL189228 | — | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL191263 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL191419 | — | EC50 | = | 575.0 | nM | 6.24 |
| CHEMBL189532 | — | EC50 | = | 725.0 | nM | 6.14 |
| CHEMBL370285 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL158781 | — | EC50 | = | 1590.0 | nM | 5.80 |