Compound Detail
CHEMBL189532
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL189532 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFMSQWAOWRDRJX-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
326.8
MW (Da)
3.55
ALogP
3
HBA
1
HBD
49.4
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta CHEMBL4093 | EC50 | 6.24 | 6.24 | 575.0 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | EC50 | 6.14 | 6.14 | 725.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.34 | 5.34 | 4550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta | EC50 | = | 575.0 | nM | 6.24 | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to... | 16107141 |
| Oxysterols receptor LXR-alpha | EC50 | = | 725.0 | nM | 6.14 | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to... | 16107141 |
| Unchecked | EC50 | = | 4550.0 | nM | 5.34 | Effective concentration in human ATP binding cassette transporter A1 (ABCA1) tra... | 16107141 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16107141 | 10.1021/jm050532w | Oxysterols receptor LXR-alpha | 3 |
| 16107141 | 10.1021/jm050532w | Unchecked | 2 |
| 16107141 | 10.1021/jm050532w | Oxysterols receptor LXR-beta | 1 |
| 16107141 | 10.1021/jm050532w | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine