Assay Detail
Binding
CHEMBL839766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.02 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.16 |
| CHEMBL189938 | — | — | 1 | 7.10 |
| CHEMBL59030 | — | — | 1 | 6.77 |
| CHEMBL191419 | — | — | 1 | 6.08 |
| CHEMBL189228 | — | — | 1 | 5.95 |
| CHEMBL364666 | — | — | 1 | 5.88 |
| CHEMBL190901 | — | — | 1 | 5.85 |
| CHEMBL370285 | — | — | 1 | 5.75 |
| CHEMBL189532 | — | — | 1 | 5.34 |
| CHEMBL158781 | — | — | 1 | 5.33 |
| CHEMBL191263 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL189938 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL59030 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL191419 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL189228 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL364666 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL190901 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL370285 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL189532 | — | EC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL158781 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL191263 | — | EC50 | = | 10170.0 | nM | 4.99 |