Assay Detail
Binding
CHEMBL829404
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Inhibition of human matrix metalloprotease-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.93 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.09 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.26 |
| CHEMBL179288 | — | — | 1 | 6.83 |
| CHEMBL362651 | — | — | 1 | 5.52 |
| CHEMBL181244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL179288 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL362651 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL181244 | — | IC50 | > | 50000.0 | nM | - |