Assay Detail
Binding
CHEMBL829417
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Inhibition of Vascular endothelial growth factor receptor 2 (KDR)
45
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isoindolinone ureas: a novel class of KDR kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.73 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410711 | — | — | 1 | 8.15 |
| CHEMBL184274 | — | — | 1 | 8.00 |
| CHEMBL183803 | — | — | 1 | 7.85 |
| CHEMBL184971 | — | — | 1 | 7.75 |
| CHEMBL183844 | — | — | 1 | 7.72 |
| CHEMBL184223 | — | — | 1 | 7.68 |
| CHEMBL184170 | — | — | 1 | 7.64 |
| CHEMBL427321 | — | — | 1 | 7.54 |
| CHEMBL185522 | — | — | 1 | 7.52 |
| CHEMBL183174 | — | — | 1 | 7.47 |
| CHEMBL427139 | — | — | 1 | 7.41 |
| CHEMBL184706 | — | — | 1 | 7.36 |
| CHEMBL182468 | — | — | 1 | 7.34 |
| CHEMBL184847 | — | — | 1 | 7.30 |
| CHEMBL185197 | — | — | 1 | 7.28 |
| CHEMBL184021 | — | — | 1 | 7.19 |
| CHEMBL185614 | — | — | 1 | 7.15 |
| CHEMBL184226 | — | — | 1 | 7.08 |
| CHEMBL185569 | — | — | 2 | 7.01 |
| CHEMBL162 | — | — | 1 | 6.94 |
| CHEMBL365448 | — | — | 1 | 6.90 |
| CHEMBL364626 | — | — | 1 | 6.79 |
| CHEMBL45651 | — | — | 1 | 6.58 |
| CHEMBL359947 | — | — | 1 | 6.46 |
| CHEMBL184143 | — | — | 1 | 6.43 |
| CHEMBL181654 | — | — | 1 | 6.37 |
| CHEMBL183025 | — | — | 1 | 6.33 |
| CHEMBL182648 | — | — | 1 | 6.28 |
| CHEMBL360032 | — | — | 1 | 6.24 |
| CHEMBL185331 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410711 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL184274 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183803 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL184971 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL183844 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL184223 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL184170 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL427321 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL185522 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL183174 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL427139 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL184706 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL182468 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL184847 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL185197 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL184021 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL185614 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL184226 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL185569 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL185569 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL162 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL365448 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL364626 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL45651 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL359947 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL184143 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL181654 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL183025 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL182648 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL360032 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL185331 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL184997 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL185477 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL185477 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL359795 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL360724 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL184604 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL185059 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL183051 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL184918 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL183580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185207 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185387 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL361285 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL297363 | — | IC50 | > | 50.0 | nM | - |