Compound Detail
CHEMBL185477
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL185477 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYRHDBQVTFEVNI-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
4.24
ALogP
2
HBA
3
HBD
70.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.75 | 5.75 | 1800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of Vascular endothelial growth factor receptor 2 (KDR) | 15357981 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of Vascular endothelial growth factor receptor 2 (KDR) | 15357981 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15357981 | 10.1016/j.bmcl.2004.06.041 | Vascular endothelial growth factor receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine