Assay Detail
Binding
CHEMBL829439
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Inhibition of Cyclin A-cyclin-dependent kinase 2
75
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Benzodipyrazoles: a new class of potent CDK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 6.93 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360520 | — | — | 1 | 9.52 |
| CHEMBL361595 | — | — | 1 | 9.00 |
| CHEMBL181036 | — | — | 1 | 8.70 |
| CHEMBL181616 | — | — | 1 | 8.70 |
| CHEMBL182209 | — | — | 1 | 8.70 |
| CHEMBL361862 | — | — | 1 | 8.40 |
| CHEMBL179588 | — | — | 1 | 8.30 |
| CHEMBL178827 | — | — | 1 | 8.10 |
| CHEMBL178190 | — | — | 1 | 8.10 |
| CHEMBL178629 | — | — | 1 | 8.05 |
| CHEMBL554716 | — | — | 1 | 8.05 |
| CHEMBL178750 | — | — | 1 | 8.00 |
| CHEMBL178478 | — | — | 1 | 7.89 |
| CHEMBL360986 | — | — | 2 | 7.85 |
| CHEMBL367798 | — | — | 1 | 7.82 |
| CHEMBL360480 | — | — | 1 | 7.75 |
| CHEMBL178572 | — | — | 1 | 7.70 |
| CHEMBL181790 | — | — | 1 | 7.70 |
| CHEMBL368043 | — | — | 1 | 7.55 |
| CHEMBL369522 | — | — | 1 | 7.55 |
| CHEMBL181223 | — | — | 1 | 7.54 |
| CHEMBL359461 | — | — | 1 | 7.54 |
| CHEMBL178408 | — | — | 1 | 7.52 |
| CHEMBL362829 | — | — | 1 | 7.44 |
| CHEMBL362656 | — | — | 1 | 7.43 |
| CHEMBL180379 | — | — | 1 | 7.40 |
| CHEMBL367363 | — | — | 1 | 7.21 |
| CHEMBL179599 | — | — | 1 | 7.12 |
| CHEMBL362004 | — | — | 1 | 7.11 |
| CHEMBL426059 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360520 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL361595 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL181616 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL182209 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL181036 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL361862 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL179588 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL178827 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL178190 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL178629 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL554716 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL178750 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL178478 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL360986 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL367798 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL360480 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL181790 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL178572 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL368043 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL369522 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL359461 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL181223 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL178408 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL362829 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL362656 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL180379 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL367363 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL179599 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL362004 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL426059 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL178452 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL181828 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL179548 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL360986 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL360695 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL181462 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL178505 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL180265 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL180715 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL359737 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL360312 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL179921 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL360149 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL178107 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL368433 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL179511 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL440379 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL178183 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL182256 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL179112 | — | IC50 | = | 310.0 | nM | 6.51 |