Assay Detail
Binding
CHEMBL829442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Epidermal growth factor receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.71 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363130 | — | — | 1 | 5.08 |
| CHEMBL363607 | — | — | 1 | 4.34 |
| CHEMBL261720 | — | — | 1 | - |
| CHEMBL191003 | JNJ-7706621 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363130 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL363607 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL261720 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191003 | JNJ-7706621 | IC50 | > | 100000.0 | nM | - |