Assay Detail
Binding
CHEMBL829448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human fibroblast growth factor receptor 1
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.32 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190980 | — | — | 1 | 7.85 |
| CHEMBL195398 | — | — | 1 | 7.80 |
| CHEMBL195847 | — | — | 1 | 7.75 |
| CHEMBL365318 | — | — | 1 | 7.72 |
| CHEMBL193306 | — | — | 1 | 7.70 |
| CHEMBL191913 | — | — | 1 | 7.57 |
| CHEMBL371373 | — | — | 1 | 7.55 |
| CHEMBL192101 | — | — | 1 | 7.48 |
| CHEMBL373365 | — | — | 1 | 7.41 |
| CHEMBL370266 | — | — | 1 | 7.34 |
| CHEMBL193136 | — | — | 1 | 7.30 |
| CHEMBL195218 | — | — | 1 | 7.24 |
| CHEMBL194872 | — | — | 1 | 7.17 |
| CHEMBL370023 | — | — | 1 | 7.08 |
| CHEMBL370515 | — | — | 1 | 6.96 |
| CHEMBL194929 | — | — | 1 | 6.85 |
| CHEMBL372662 | — | — | 1 | 6.83 |
| CHEMBL195771 | — | — | 1 | 6.80 |
| CHEMBL195903 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190980 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL195398 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL195847 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL365318 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL193306 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL191913 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL371373 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL192101 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL373365 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL370266 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL193136 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL195218 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL194872 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL370023 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL370515 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL194929 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL372662 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL195771 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL195903 | — | IC50 | = | 220.0 | nM | 6.66 |