Assay Detail
Binding
CHEMBL829463
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In vitro inhibitory concentration against heme oxygenase 1 from rat spleen
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.32 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421109 | — | — | 1 | 6.28 |
| CHEMBL179494 | — | — | 1 | 5.80 |
| CHEMBL368045 | — | — | 1 | 5.60 |
| CHEMBL360897 | — | — | 1 | 5.40 |
| CHEMBL361591 | — | — | 1 | 5.30 |
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 5.22 |
| CHEMBL70396 | — | — | 1 | 4.57 |
| CHEMBL305220 | — | — | 1 | 4.40 |
| CHEMBL360886 | — | — | 1 | - |
| CHEMBL179226 | — | — | 1 | - |
| CHEMBL441500 | — | — | 1 | - |
| CHEMBL178891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421109 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL179494 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL368045 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL360897 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL361591 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL70611 | AZALANSTAT | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL70396 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL305220 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL360886 | — | IC50 | 1000.0 | nM | - | |
| CHEMBL179226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL441500 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL178891 | — | IC50 | > | 100000.0 | nM | - |