Assay Detail
Binding
CHEMBL829472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360349 | — | — | 1 | 7.89 |
| CHEMBL179815 | — | — | 1 | 7.77 |
| CHEMBL178455 | — | — | 1 | 7.17 |
| CHEMBL279351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360349 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL179815 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL178455 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL279351 | — | IC50 | < | 3.0 | nM | - |