Assay Detail
Binding
CHEMBL829490
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Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and specificity studies of small-molecule ligands for SH3 protein domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 4.39 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185932 | — | — | 1 | 4.66 |
| CHEMBL366327 | — | — | 1 | 4.40 |
| CHEMBL426622 | — | — | 1 | 4.28 |
| CHEMBL361660 | — | — | 1 | 4.21 |
| CHEMBL187951 | — | — | 1 | - |
| CHEMBL61236 | — | — | 1 | - |
| CHEMBL62083 | — | — | 1 | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | - |
| CHEMBL319543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185932 | — | Kd | = | 22000.0 | nM | 4.66 |
| CHEMBL366327 | — | Kd | = | 40000.0 | nM | 4.40 |
| CHEMBL426622 | — | Kd | = | 52000.0 | nM | 4.28 |
| CHEMBL361660 | — | Kd | = | 61000.0 | nM | 4.21 |
| CHEMBL187951 | — | Kd | = | 800000.0 | nM | - |
| CHEMBL61236 | — | Kd | = | 125000.0 | nM | - |
| CHEMBL62083 | — | Kd | = | 650000.0 | nM | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | Kd | > | 4000000.0 | nM | - |
| CHEMBL319543 | — | Kd | = | 380000.0 | nM | - |