Assay Detail
Binding
CHEMBL829497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Butyrylcholinesterase from human erythrocytes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.03 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534932 | — | — | 1 | 8.32 |
| CHEMBL535812 | — | — | 1 | 8.26 |
| CHEMBL557155 | — | — | 1 | 8.17 |
| CHEMBL538573 | — | — | 1 | 8.13 |
| CHEMBL555666 | — | — | 1 | 8.11 |
| CHEMBL539599 | — | — | 1 | 8.11 |
| CHEMBL555214 | — | — | 1 | 7.85 |
| CHEMBL2113368 | — | — | 1 | 7.79 |
| CHEMBL2113367 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534932 | — | IC50 | = | 4.74 | nM | 8.32 |
| CHEMBL535812 | — | IC50 | = | 5.55 | nM | 8.26 |
| CHEMBL557155 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL538573 | — | IC50 | = | 7.38 | nM | 8.13 |
| CHEMBL555666 | — | IC50 | = | 7.69 | nM | 8.11 |
| CHEMBL539599 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL555214 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2113368 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL2113367 | — | IC50 | = | 31.1 | nM | 7.51 |