Assay Detail
Binding
CHEMBL829506
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Inhibitory concentration against human inducible nitric oxide synthase expressed in Sf-9 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.67 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106516 | THIOCITRULLINE | — | 1 | 6.52 |
| CHEMBL196720 | — | — | 1 | 5.41 |
| CHEMBL11471 | L-NIO | — | 1 | 5.40 |
| CHEMBL193967 | — | — | 1 | 5.35 |
| CHEMBL196721 | — | — | 1 | - |
| CHEMBL197055 | — | — | 1 | - |
| CHEMBL370170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106516 | THIOCITRULLINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL196720 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL11471 | L-NIO | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL193967 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL196721 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL197055 | — | IC50 | = | 370000.0 | nM | - |
| CHEMBL370170 | — | IC50 | > | 1000000.0 | nM | - |