Assay Detail
Binding
CHEMBL829511
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Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.45 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443565 | — | — | 1 | 7.80 |
| CHEMBL178116 | — | — | 1 | 6.66 |
| CHEMBL425699 | — | — | 1 | 6.31 |
| CHEMBL360355 | — | — | 1 | 6.00 |
| CHEMBL360020 | — | — | 1 | 5.78 |
| CHEMBL181768 | — | — | 1 | 5.76 |
| CHEMBL366927 | — | — | 1 | 5.68 |
| CHEMBL361613 | — | — | 1 | 5.68 |
| CHEMBL447233 | — | — | 1 | 5.65 |
| CHEMBL433771 | — | — | 1 | 5.61 |
| CHEMBL181775 | — | — | 1 | 5.56 |
| CHEMBL362191 | — | — | 1 | 5.54 |
| CHEMBL180763 | — | — | 1 | 5.48 |
| CHEMBL179503 | — | — | 1 | 5.39 |
| CHEMBL367356 | — | — | 1 | 5.37 |
| CHEMBL220238 | — | — | 1 | 5.31 |
| CHEMBL180623 | — | — | 1 | 5.28 |
| CHEMBL441118 | — | — | 1 | 5.22 |
| CHEMBL180669 | — | — | 1 | 5.22 |
| CHEMBL424789 | — | — | 1 | 5.21 |
| CHEMBL361825 | — | — | 1 | 5.19 |
| CHEMBL360956 | — | — | 1 | 5.19 |
| CHEMBL180273 | — | — | 1 | 5.18 |
| CHEMBL360788 | — | — | 1 | 5.13 |
| CHEMBL359643 | — | — | 1 | 5.12 |
| CHEMBL178280 | — | — | 1 | 5.12 |
| CHEMBL362213 | — | — | 1 | 5.08 |
| CHEMBL180646 | — | — | 1 | 5.04 |
| CHEMBL178674 | — | — | 1 | 5.04 |
| CHEMBL360915 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443565 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL178116 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL425699 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL360355 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL360020 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL181768 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL366927 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL361613 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL447233 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL433771 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL181775 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL362191 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL180763 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL179503 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL367356 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL220238 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL180623 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL441118 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL180669 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL424789 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL361825 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL360956 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL180273 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL360788 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL178280 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL359643 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL362213 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL180646 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL178674 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL360915 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL181274 | — | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL369290 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL179066 | — | IC50 | = | 9570.0 | nM | 5.02 |
| CHEMBL182103 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL178339 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL362074 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL361983 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL434147 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL359542 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL178775 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181027 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL264344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL179551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181623 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL359598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL178514 | — | IC50 | > | 10000.0 | nM | - |