Assay Detail
Binding
CHEMBL829512
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Inhibitory concentration against human plasma Butyrylcholinesterase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.16 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367795 | — | — | 1 | 8.70 |
| CHEMBL361409 | — | — | 1 | 8.40 |
| CHEMBL362444 | — | — | 1 | 8.40 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 8.30 |
| CHEMBL369554 | — | — | 1 | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.80 |
| CHEMBL178132 | — | — | 1 | 7.77 |
| CHEMBL178792 | — | — | 1 | 7.66 |
| CHEMBL362704 | — | — | 1 | 7.62 |
| CHEMBL179320 | — | — | 1 | 7.57 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.43 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.33 |
| CHEMBL417915 | — | — | 1 | 7.30 |
| CHEMBL74926 | PHENSERINE | — | 1 | 5.81 |
| CHEMBL362049 | — | — | 1 | 5.81 |
| CHEMBL539624 | — | — | 1 | 5.77 |
| CHEMBL300143 | — | — | 1 | 5.71 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.38 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.14 |
| CHEMBL178770 | — | — | 1 | - |
| CHEMBL178294 | — | — | 1 | - |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367795 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL361409 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL362444 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL369554 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL178132 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL178792 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL362704 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL179320 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL95 | TACRINE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL417915 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL362049 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL539624 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL300143 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL178770 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL178294 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL395280 | HUPERZINE A | IC50 | > | 10000.0 | nM | - |