Assay Detail
Binding
CHEMBL829513
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Inhibitory concentration against Butyrylcholinesterase from human erythrocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 7.36 |
| CHEMBL536047 | — | — | 1 | 6.63 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 43.9 | nM | 7.36 |
| CHEMBL536047 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL395280 | HUPERZINE A | IC50 | > | 10000.0 | nM | - |