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Assay Detail

CHEMBL829548

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human 5-hydroxytryptamine 1D receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1D (CHEMBL1983)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA.
Bioorg Med Chem Lett (2004) 14 : 4697 -4699
PubMed 15324890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.29 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366322 1 9.52
CHEMBL312448 XYLOMETAZOLINE 3.0 1 9.15
CHEMBL361729 1 7.52
CHEMBL361470 1 7.48
CHEMBL360803 PI-CLONIDINE 1 7.30
CHEMBL182837 1 7.27
CHEMBL307408 1 7.13
CHEMBL276868 1 6.98
CHEMBL183704 1 6.48
CHEMBL186919 1 5.68
CHEMBL71033 1 5.66
CHEMBL770 TOLAZOLINE 4.0 1 -
CHEMBL186961 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366322 Ki = 0.3 nM 9.52
CHEMBL312448 XYLOMETAZOLINE Ki = 0.7 nM 9.15
CHEMBL361729 Ki = 30.0 nM 7.52
CHEMBL361470 Ki = 33.0 nM 7.48
CHEMBL360803 PI-CLONIDINE Ki = 50.0 nM 7.30
CHEMBL182837 Ki = 54.0 nM 7.27
CHEMBL307408 Ki = 74.0 nM 7.13
CHEMBL276868 Ki = 105.0 nM 6.98
CHEMBL183704 Ki = 330.0 nM 6.48
CHEMBL186919 Ki = 2075.0 nM 5.68
CHEMBL71033 Ki = 2210.0 nM 5.66
CHEMBL770 TOLAZOLINE Ki > 10000.0 nM -
CHEMBL186961 Ki > 30000.0 nM -