Assay Detail
Binding
CHEMBL829566
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Inhibition of adenylyl cyclase activity in rat cortical membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193521 | — | — | 1 | 8.94 |
| CHEMBL444550 | — | — | 1 | 6.99 |
| CHEMBL2113608 | — | — | 1 | 6.55 |
| CHEMBL611115 | — | — | 1 | 6.52 |
| CHEMBL481858 | — | — | 1 | 5.40 |
| CHEMBL2113607 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193521 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL444550 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2113608 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL611115 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL481858 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL2113607 | — | IC50 | = | 4908.0 | nM | 5.31 |