Assay Detail
Binding
CHEMBL829574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human ECE-1 expressed in MDCK cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.32 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367315 | — | — | 1 | 7.17 |
| CHEMBL194651 | — | — | 1 | 7.14 |
| CHEMBL191879 | — | — | 1 | 7.12 |
| CHEMBL193490 | — | — | 1 | 6.32 |
| CHEMBL192441 | — | — | 1 | 5.96 |
| CHEMBL425383 | — | — | 1 | 5.60 |
| CHEMBL177000 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367315 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL194651 | — | IC50 | = | 72.9 | nM | 7.14 |
| CHEMBL191879 | — | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL193490 | — | IC50 | = | 480.5 | nM | 6.32 |
| CHEMBL192441 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL425383 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL177000 | — | IC50 | = | 10890.0 | nM | 4.96 |