Assay Detail
Binding
CHEMBL829582
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Concentration required to inhibit human mitogen activated protein kinase p38 activity
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.19 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183630 | — | — | 1 | 8.00 |
| CHEMBL183999 | — | — | 1 | 8.00 |
| CHEMBL184012 | — | — | 1 | 8.00 |
| CHEMBL184387 | — | — | 1 | 8.00 |
| CHEMBL365688 | — | — | 1 | 7.70 |
| CHEMBL264502 | — | — | 1 | 7.70 |
| CHEMBL186791 | — | — | 1 | 7.70 |
| CHEMBL10 | SB-203580 | — | 1 | 7.70 |
| CHEMBL184712 | — | — | 1 | 7.70 |
| CHEMBL184721 | — | — | 1 | 7.52 |
| CHEMBL365929 | — | — | 1 | 7.52 |
| CHEMBL187378 | — | — | 1 | 7.30 |
| CHEMBL366255 | — | — | 1 | 7.30 |
| CHEMBL185448 | — | — | 1 | 7.22 |
| CHEMBL186531 | — | — | 1 | 7.22 |
| CHEMBL182396 | — | — | 1 | 7.05 |
| CHEMBL445920 | — | — | 1 | 7.05 |
| CHEMBL187327 | — | — | 1 | 7.00 |
| CHEMBL365472 | — | — | 1 | 6.77 |
| CHEMBL184011 | — | — | 1 | 6.75 |
| CHEMBL413558 | — | — | 1 | 6.75 |
| CHEMBL186526 | — | — | 1 | 6.75 |
| CHEMBL183100 | — | — | 1 | 6.66 |
| CHEMBL186542 | — | — | 1 | 6.64 |
| CHEMBL184189 | — | — | 1 | 6.57 |
| CHEMBL185086 | — | — | 1 | 6.51 |
| CHEMBL184347 | — | — | 1 | 6.47 |
| CHEMBL188122 | — | — | 1 | 5.72 |
| CHEMBL183843 | — | — | 1 | - |
| CHEMBL187055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183630 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183999 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL184012 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL184387 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL365688 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL264502 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL186791 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL10 | SB-203580 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184712 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184721 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL365929 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187378 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL366255 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL185448 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL186531 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL182396 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL445920 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL187327 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL365472 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL184011 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL413558 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL186526 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL183100 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL186542 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL184189 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL185086 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL184347 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL188122 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL183843 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL187055 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL186956 | — | IC50 | > | 20000.0 | nM | - |