Assay Detail
Binding
CHEMBL829602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-nisoxetine from norepinephrine transporter of rat cerebral corticex homogenate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.38 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365623 | — | — | 1 | 8.99 |
| CHEMBL184123 | — | — | 1 | 8.69 |
| CHEMBL184807 | — | — | 1 | 8.05 |
| CHEMBL186119 | — | — | 1 | 7.82 |
| CHEMBL97887 | — | — | 1 | 7.82 |
| CHEMBL318961 | — | — | 1 | 6.94 |
| CHEMBL433159 | — | — | 1 | 6.71 |
| CHEMBL362565 | — | — | 1 | 6.65 |
| CHEMBL365649 | — | — | 1 | 6.61 |
| CHEMBL185608 | — | — | 1 | 6.55 |
| CHEMBL187299 | — | — | 1 | 6.38 |
| CHEMBL183259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365623 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL184123 | — | Ki | = | 2.03 | nM | 8.69 |
| CHEMBL184807 | — | Ki | = | 8.85 | nM | 8.05 |
| CHEMBL186119 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL97887 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL318961 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL433159 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL362565 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL365649 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL185608 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL187299 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL183259 | — | Ki | > | 10000.0 | nM | - |