Assay Detail
Binding
CHEMBL829632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193639 | — | — | 2 | 8.52 |
| CHEMBL363581 | — | — | 1 | 7.72 |
| CHEMBL366164 | — | — | 1 | 7.66 |
| CHEMBL329566 | — | — | 1 | 7.20 |
| CHEMBL435301 | — | — | 1 | 7.08 |
| CHEMBL193435 | — | — | 1 | 6.81 |
| CHEMBL364270 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193639 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL193639 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL363581 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL366164 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL329566 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL435301 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL193435 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL364270 | — | Ki | = | 250.0 | nM | 6.60 |