Assay Detail
Binding
CHEMBL829671
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Inhibition of phosphodiesterase 5 in rat fetal lung fibroblast (RFL-6) cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RFL-6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL4567) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 9.42 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425690 | — | — | 1 | 10.72 |
| CHEMBL369621 | — | — | 1 | 9.92 |
| CHEMBL367206 | — | — | 1 | 9.82 |
| CHEMBL178056 | — | — | 1 | 9.77 |
| CHEMBL177881 | — | — | 1 | 9.72 |
| CHEMBL177427 | — | — | 1 | 9.66 |
| CHEMBL360793 | — | — | 1 | 9.62 |
| CHEMBL178693 | — | — | 1 | 9.62 |
| CHEMBL355574 | — | — | 1 | 9.54 |
| CHEMBL367142 | — | — | 1 | 9.48 |
| CHEMBL178541 | — | — | 1 | 9.44 |
| CHEMBL173728 | — | — | 1 | 9.29 |
| CHEMBL280439 | — | — | 1 | 9.28 |
| CHEMBL130811 | — | — | 1 | 9.28 |
| CHEMBL175987 | — | — | 1 | 9.19 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.74 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.30 |
| CHEMBL369259 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425690 | — | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL369621 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL367206 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL178056 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL177881 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL177427 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL360793 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL178693 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL355574 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL367142 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL178541 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL173728 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL280439 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL130811 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL175987 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL192 | SILDENAFIL | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL779 | TADALAFIL | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL369259 | — | Ki | = | 6.43 | nM | 8.19 |