Compound Detail
CHEMBL369259
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL369259 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PQOYPPUGRGEVJD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
458.5
MW (Da)
5.44
ALogP
6
HBA
1
HBD
71.4
PSA (Ų)
0.39
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL4567 | Ki | 8.19 | 8.19 | 6.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | Ki | = | 6.43 | nM | 8.19 | Inhibition of phosphodiesterase 5 in rat fetal lung fibroblast (RFL-6) cells | 15771456 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15771456 | 10.1021/jm0401098 | Unchecked | 6 |
| 15771456 | 10.1021/jm0401098 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine