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Assay Detail

CHEMBL829677

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DAMGO from mu opioid receptor of rat brain membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mu-type opioid receptor (CHEMBL270)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.
Spetea M, Greiner E, Aceto MD, Harris LS, Coop A, Schmidhammer H.
J Med Chem (2005) 48 : 5052 -5055
PubMed 16033285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.77 8.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL70 MORPHINE 4.0 1 8.18
CHEMBL656 OXYCODONE 4.0 1 7.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL70 MORPHINE Ki = 6.55 nM 8.18
CHEMBL656 OXYCODONE Ki = 43.6 nM 7.36