Assay Detail
Binding
CHEMBL829699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant determined against recombinant Fatty-acid amide hydrolase from human expressed in COS-7 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.80 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177577 | — | — | 1 | 8.05 |
| CHEMBL426230 | — | — | 1 | 8.00 |
| CHEMBL39412 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177577 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL426230 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL39412 | — | Ki | = | 45.0 | nM | 7.35 |