Assay Detail
Binding
CHEMBL829786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
GABA A receptor alpha-2/beta-2/gamma-2 (CHEMBL2111327) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.43 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372281 | — | — | 1 | 7.86 |
| CHEMBL192554 | — | — | 1 | 7.84 |
| CHEMBL191088 | — | — | 1 | 7.75 |
| CHEMBL192555 | — | — | 1 | 7.56 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372281 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL192554 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL191088 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL192555 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 765.0 | nM | 6.12 |