Assay Detail
Binding
CHEMBL829831
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Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RH7777 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.99 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361501 | — | — | 1 | 6.37 |
| CHEMBL188591 | — | — | 1 | 6.34 |
| CHEMBL188859 | — | — | 1 | 6.10 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | — | 1 | 5.97 |
| CHEMBL190430 | — | — | 1 | 5.94 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | — | 1 | 5.87 |
| CHEMBL191055 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361501 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL188591 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL188859 | — | Ki | = | 788.0 | nM | 6.10 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | Ki | = | 1082.0 | nM | 5.97 |
| CHEMBL190430 | — | Ki | = | 1146.0 | nM | 5.94 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | Ki | = | 1354.0 | nM | 5.87 |
| CHEMBL191055 | — | Ki | = | 4300.0 | nM | 5.37 |