Assay Detail
Binding
CHEMBL829871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Farnesoid X receptor in FRET assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 5.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318457 | — | — | 1 | 7.52 |
| CHEMBL566315 | OBETICHOLIC ACID | 4.0 | 1 | 7.05 |
| CHEMBL3138060 | — | — | 1 | 6.32 |
| CHEMBL3138036 | — | — | 1 | 6.27 |
| CHEMBL3137829 | — | — | 1 | 6.12 |
| CHEMBL3138327 | — | — | 1 | 5.92 |
| CHEMBL3138034 | — | — | 1 | 5.91 |
| CHEMBL270311 | — | — | 1 | 5.89 |
| CHEMBL3138041 | — | — | 1 | 5.61 |
| CHEMBL3138403 | — | — | 1 | 5.57 |
| CHEMBL3138038 | — | — | 1 | 5.34 |
| CHEMBL3138058 | — | — | 1 | 5.22 |
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 5.06 |
| CHEMBL3138044 | — | — | 1 | 5.01 |
| CHEMBL3138040 | — | — | 1 | 4.99 |
| CHEMBL3138406 | — | — | 1 | 4.88 |
| CHEMBL3138054 | — | — | 1 | 4.83 |
| CHEMBL3138311 | — | — | 1 | 4.82 |
| CHEMBL3138043 | — | — | 1 | 4.81 |
| CHEMBL3138037 | — | — | 1 | 4.48 |
| CHEMBL3138035 | — | — | 1 | 4.37 |
| CHEMBL3138046 | — | — | 1 | 4.21 |
| CHEMBL3138042 | — | — | 1 | - |
| CHEMBL3138059 | — | — | 1 | - |
| CHEMBL3138052 | — | — | 1 | - |
| CHEMBL3138317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318457 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL566315 | OBETICHOLIC ACID | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3138060 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3138036 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3137829 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3138327 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3138034 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL270311 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3138041 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3138403 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL3138038 | — | EC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL3138058 | — | EC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL240597 | CHENODIOL | EC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL3138044 | — | EC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL3138040 | — | EC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL3138406 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3138054 | — | EC50 | = | 14730.0 | nM | 4.83 |
| CHEMBL3138311 | — | EC50 | = | 15110.0 | nM | 4.82 |
| CHEMBL3138043 | — | EC50 | = | 15620.0 | nM | 4.81 |
| CHEMBL3138037 | — | EC50 | = | 33180.0 | nM | 4.48 |
| CHEMBL3138035 | — | EC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL3138046 | — | EC50 | = | 61150.0 | nM | 4.21 |
| CHEMBL3138042 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3138059 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3138052 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3138317 | — | EC50 | > | 30000.0 | nM | - |