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Assay Detail

CHEMBL829951

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Neuromedin-B receptor (CHEMBL3636)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study.
Nock BA, Nikolopoulou A, Galanis A, Cordopatis P, Waser B, Reubi JC, Maina T.
J Med Chem (2005) 48 : 100 -110
PubMed 15634004 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 8.70 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414307 1 9.05
CHEMBL413893 UNIVERSAL LIGAND 1 9.02
CHEMBL2371725 Demobesin 3 1 8.80
CHEMBL266079 1 8.70
CHEMBL2371724 1 7.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414307 IC50 = 0.9 nM 9.05
CHEMBL413893 UNIVERSAL LIGAND IC50 = 0.96 nM 9.02
CHEMBL2371725 Demobesin 3 IC50 = 1.6 nM 8.80
CHEMBL266079 IC50 = 2.0 nM 8.70
CHEMBL2371724 IC50 = 11.2 nM 7.95