Assay Detail
Binding
CHEMBL829990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for estrogen receptor (ER) alpha of MCF-7 cell cytosol incubated with 2 nM [3H]estradiol; Agonist
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.57 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | — | 1 | 6.88 |
| CHEMBL179243 | — | — | 1 | 6.87 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 6.58 |
| CHEMBL175525 | — | — | 1 | 6.42 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311636 | 8Z-3,4',5-TRIMETHOXYSTILBENE | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL179243 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL175525 | — | Ki | = | 380.8 | nM | 6.42 |
| CHEMBL165 | RESVERATROL | Ki | = | 785.0 | nM | 6.11 |